When overwhelmed with stress, cells can enter a zombie-like state called senescence. The build-up of these cells in the brain has been linked to several diseases. Bough Biosciences will develop a novel approach to discover senolytics, drugs that remove senescent cells. We will tailor and develop disease-specific senolytics using single cell-RNA sequencing to build models to understand what causes the build-up of these cells in different diseases. Understanding these features allows us to model disease-specific cellular senescence in a petri dish outside the human body and identify potent compounds specific for the senescent cells in neurological and neuropsychiatric disease.